The study is aimed to evaluate efficacy and safety of re-irradiation for patients with recurrent high grade gliomas after other treatment.
Inclusion Criteria: * Age \> 18 years * Karnosky performance status (KPS) ≥70 * Patients aged \>70 years with KPS ≥80 * Histopathologically confirmed grade III-IV glioma * Estimated survival ≥ 3 months * Any Tumor volume * Unifocal tumor * Interval time from previous radiotherapy ≥ 6mesi * Normal liver, Kidney and bone marrow function * Written informed consent Exclusion Criteria: * KPS \< 70 * Multifocal tumor * Other primary cancer * Pregnant women