COMPLETEDNA

Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients

The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer

Sponsor

Chulabhorn Cancer Center

Enrollment

150 participants

Sites

1 locations

Start Date

May 2016

Completion

April 2018

RadiodermatitisBreast NeoplasmsAdverse Effect of Radiation TherapyControlCucumber cream

Enrollment & Timeline

Completed

Target N

150

participants

Sites

locations

Duration

2.1 years

total trial span

Rate

pts/month needed

At 1 sites, each site needs to enroll approximately 6.0 patients/month to hit the enrollment target on schedule.

View on ClinicalTrials.gov

Ask AI

Primary Outcomes

Change of dermatitis grading

Change from baseline dermatitis grading at 1, 2, 3, 4, 5 weeks and at 9 week.

RTOG (Radiation Therapy Oncology Group) Cooperative Group Common Toxicity Criteria Skin Grade 0:None or no change Grade 1:Scattered macular or papular eruption or erythema that is asymptomatic Grade 2:Scattered macular or papular eruption or erythema with pruritis or other associated symptoms Grade 3:Generalized symptomatic macular, papular, or vesicular eruption Grade 4:Exfoliative dermatitis or ulcerating dermatitis Grade 5:If that toxicity caused the death of the patient.

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats.

Chen Y J, Dai Y S, Chen B F et al.Biological & pharmaceutical bulletin1999

DOI PubMed

Moist skin care can diminish acute radiation-induced skin toxicity.

Momm Felix, Weissenberger Christian, Bartelt Susanne et al.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2003

DOI PubMed

Evidence-based skin care management in radiation therapy.

McQuestion MaureneSeminars in oncology nursing2006

DOI PubMed

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats.

Haleagrahara Nagaraja, Ponnusamy KumarThe Journal of toxicological sciences2010

DOI PubMed

Cucumis sativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent.

Nema Neelesh K, Maity Niladri, Sarkar B et al.Archives of dermatological research2011

DOI PubMed

Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.

Gohil Kashmira J, Patel Jagruti A, Gajjar Anuradha KIndian journal of pharmaceutical sciences2011

DOI PubMed

Chemical composition and antimicrobial activity of Cymbopogon nardus citronella essential oil against systemic bacteria of aquatic animals.

Wei Lee Seong, Wee WendyIranian journal of microbiology2013

PubMed

Radioprotective agents for radiation therapy: future trends.

Johnke Roberta M, Sattler Jennifer A, Allison Ron RFuture oncology (London, England)2015

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Fetching protocol from ClinicalTrials.gov…

COMPLETEDNA

Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients

The herbal products on reduction of radiation-induced dermatitis in patients with breast cancer

Sponsor

Chulabhorn Cancer Center

Enrollment

150 participants

Sites

1 locations

Start Date

May 2016

Completion

April 2018

RadiodermatitisBreast NeoplasmsAdverse Effect of Radiation TherapyControlCucumber cream

Enrollment & Timeline

Completed

Target N

150

participants

Sites

locations

Duration

2.1 years

total trial span

Rate

pts/month needed

At 1 sites, each site needs to enroll approximately 6.0 patients/month to hit the enrollment target on schedule.

View on ClinicalTrials.gov

Ask AI

Primary Outcomes

Change of dermatitis grading

Change from baseline dermatitis grading at 1, 2, 3, 4, 5 weeks and at 9 week.

Ask AI

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats.

Chen Y J, Dai Y S, Chen B F et al.Biological & pharmaceutical bulletin1999

DOI PubMed

Moist skin care can diminish acute radiation-induced skin toxicity.

Momm Felix, Weissenberger Christian, Bartelt Susanne et al.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2003

DOI PubMed

Evidence-based skin care management in radiation therapy.

McQuestion MaureneSeminars in oncology nursing2006

DOI PubMed

Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats.

Haleagrahara Nagaraja, Ponnusamy KumarThe Journal of toxicological sciences2010

DOI PubMed

Cucumis sativus fruit-potential antioxidant, anti-hyaluronidase, and anti-elastase agent.

Nema Neelesh K, Maity Niladri, Sarkar B et al.Archives of dermatological research2011

DOI PubMed

Pharmacological Review on Centella asiatica: A Potential Herbal Cure-all.

Gohil Kashmira J, Patel Jagruti A, Gajjar Anuradha KIndian journal of pharmaceutical sciences2011

DOI PubMed

Chemical composition and antimicrobial activity of Cymbopogon nardus citronella essential oil against systemic bacteria of aquatic animals.

Wei Lee Seong, Wee WendyIranian journal of microbiology2013

PubMed

Radioprotective agents for radiation therapy: future trends.

Johnke Roberta M, Sattler Jennifer A, Allison Ron RFuture oncology (London, England)2015

DOI PubMed

PubMed/NCBI (daily updates) FDA FAERS (quarterly updates) WHO ICTRP (weekly updates)

Ask AI

Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Effects of Herbal Products on Reduction of Radiation-induced Dermatitis in Breast Cancer Patients

Enrollment & Timeline

Primary Outcomes

Multi-Source Intelligencefrom PubMed · FDA FAERS · WHO ICTRP

Eligibility

Trial Sites (1)