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Explore/Alzheimer's disease MCI prevention

Status

Phase

Pre-filtered to show active, later-stage trials with the strongest clinical signal.

27 results for “Alzheimer's disease MCI prevention” · Phase 3 · Phase 2

Page 1 of 2

Completed

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Phase 2Phase 3Mild Cognitive Impairment

caloric restrictionomega-3 supplementationresveratrol supplementation+3 more

Charite University, Berlin, Germany330 participants1 site · GermanyCompletes Jul 2016

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Recruiting

COMMETS- Combination MCI Metabolic Syndrome

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentMetabolic Syndrome

SemaglutideIntranasal insulinSemaglutide placebo+1 more

Rutgers, The State University of New Jersey80 participants1 site · IsraelCompletes Dec 2027

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Not Yet Recruiting

Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain

Phase 3Alzheimer Disease (AD)

tributyrinPlacebo

Universidad de Almeria156 participants1 site · SpainCompletes Sep 2026

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Completed

Memory Impairment Study (Mild Cognitive Impairment Study)

Phase 3Alzheimer Disease

DonepezilVitamin E

National Institute on Aging (NIA)72 sites · United States, CanadaCompletes Jan 2004

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Completed

Results posted

Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI)

Phase 3Post-Stroke Cognitive Impairment (PSCI)

ActoveginPlacebo

Takeda503 participants14 sites · Belarus, Kazakhstan, RussiaCompletes Nov 2014

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Completed

A Trial of Cilostazol in Patients With Mild Cognitive Impairment (COMCID)

Phase 2Mild Cognitive Impairment

CilostazolPlacebo

National Cerebral and Cardiovascular Center, Japan166 participants1 site · JapanCompletes Aug 2020

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Not Yet Recruiting

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentCognitive Decline

Resveratrol, Quercetin, and Curcumin (RQC)Curcumin

Zaparackas and Knepper LTD200 participants1 site · United StatesCompletes Jul 2027

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Completed

Results posted

The Synapse Project

Phase 2Alzheimer Disease

UCB-JMRI ScanPET Scan

University of Wisconsin, Madison100 participants1 site · United StatesCompletes Oct 2023

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UNKNOWN

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Phase 2Mild Cognitive Impairment

Curcuminaerobic yoganon aerobic yoga+1 more

VA Office of Research and Development80 participants1 site · United StatesCompletes Mar 2020

Compare CT.gov Full analysis →

Completed

Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

Phase 2Alzheimer DiseaseCognitive Decline Due to Alzheimer DiseaseMild Cognitive Impairment Due to Alzheimer Disease

NaproxenPlacebo

Douglas Mental Health University Institute200 participants1 site · CanadaCompletes Mar 2017

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Recruiting

Digital STEADI Efficacy

Phase 1Phase 2FallMild Cognitive Impairment (MCI)Aging

Digital STEADI-1STEADI Standard of CareDigital STEADI-2+1 more

Friendi.fi Corporation300 participants1 site · United StatesCompletes May 2028

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Recruiting

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

Phase 2InsomniaCognitive DysfunctionMild Cognitive Impairment

SHUTi OASISPatient Education

University of Virginia144 participants1 site · United StatesCompletes Jan 2028

Compare CT.gov Full analysis →

Completed

Results posted

The Efficient Brain Study

Phase 2Metabolism - Cerebral Energy

Fermented Papaya PreparationGranulated Sugar

University of Florida30 participants1 site · United StatesCompletes Jul 2018

Compare CT.gov Full analysis →

Completed

Results posted

Metformin in Amnestic Mild Cognitive Impairment

Phase 2Mild Cognitive Impairment

MetforminPlacebo

Columbia University80 participants1 site · United StatesCompletes Feb 2012

Compare CT.gov Full analysis →

Completed

Results posted

Valacyclovir for Mild Cognitive Impairment

Phase 2Mild Cognitive ImpairmentHerpes Simplex 1Herpes Simplex 2

Valacyclovir hydrochloride 500mg capletPlacebo sugar pill caplet

New York State Psychiatric Institute50 participants1 site · United StatesCompletes Oct 2024

Compare CT.gov Full analysis →

1–15 of 27

Explore/Alzheimer's disease MCI prevention

Status

Phase

Pre-filtered to show active, later-stage trials with the strongest clinical signal.

27 results for “Alzheimer's disease MCI prevention” · Phase 3 · Phase 2

Page 1 of 2

Completed

Effects of Dietary Interventions on the Brain in Mild Cognitive Impairment (MCI)

Phase 2Phase 3Mild Cognitive Impairment

caloric restrictionomega-3 supplementationresveratrol supplementation+3 more

Charite University, Berlin, Germany330 participants1 site · GermanyCompletes Jul 2016

Compare CT.gov Full analysis →

Recruiting

COMMETS- Combination MCI Metabolic Syndrome

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentMetabolic Syndrome

SemaglutideIntranasal insulinSemaglutide placebo+1 more

Rutgers, The State University of New Jersey80 participants1 site · IsraelCompletes Dec 2027

Compare CT.gov Full analysis →

Not Yet Recruiting

Tributyrin Treatment in Mild Alzheimer Disease: Assessment of Butyrate Effects Via the Gut-Brain

Phase 3Alzheimer Disease (AD)

tributyrinPlacebo

Universidad de Almeria156 participants1 site · SpainCompletes Sep 2026

Compare CT.gov Full analysis →

Completed

Memory Impairment Study (Mild Cognitive Impairment Study)

Phase 3Alzheimer Disease

DonepezilVitamin E

National Institute on Aging (NIA)72 sites · United States, CanadaCompletes Jan 2004

Compare CT.gov Full analysis →

Completed

Results posted

Efficacy and Safety of Actovegin in Post-stroke Cognitive Impairment (PSCI)

Phase 3Post-Stroke Cognitive Impairment (PSCI)

ActoveginPlacebo

Takeda503 participants14 sites · Belarus, Kazakhstan, RussiaCompletes Nov 2014

Compare CT.gov Full analysis →

Completed

A Trial of Cilostazol in Patients With Mild Cognitive Impairment (COMCID)

Phase 2Mild Cognitive Impairment

CilostazolPlacebo

National Cerebral and Cardiovascular Center, Japan166 participants1 site · JapanCompletes Aug 2020

Compare CT.gov Full analysis →

Not Yet Recruiting

RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Phase 2Alzheimer DiseaseMild Cognitive ImpairmentCognitive Decline

Resveratrol, Quercetin, and Curcumin (RQC)Curcumin

Zaparackas and Knepper LTD200 participants1 site · United StatesCompletes Jul 2027

Compare CT.gov Full analysis →

Completed

Results posted

The Synapse Project

Phase 2Alzheimer Disease

UCB-JMRI ScanPET Scan

University of Wisconsin, Madison100 participants1 site · United StatesCompletes Oct 2023

Compare CT.gov Full analysis →

UNKNOWN

Curcumin and Yoga Therapy for Those at Risk for Alzheimer's Disease

Phase 2Mild Cognitive Impairment

Curcuminaerobic yoganon aerobic yoga+1 more

VA Office of Research and Development80 participants1 site · United StatesCompletes Mar 2020

Compare CT.gov Full analysis →

Completed

Randomized Trial of Low-dose Naproxen in Cognitively Intact Persons at Risk of Alzheimer's Dementia

Phase 2Alzheimer DiseaseCognitive Decline Due to Alzheimer DiseaseMild Cognitive Impairment Due to Alzheimer Disease

NaproxenPlacebo

Douglas Mental Health University Institute200 participants1 site · CanadaCompletes Mar 2017

Compare CT.gov Full analysis →

Recruiting

Digital STEADI Efficacy

Phase 1Phase 2FallMild Cognitive Impairment (MCI)Aging

Digital STEADI-1STEADI Standard of CareDigital STEADI-2+1 more

Friendi.fi Corporation300 participants1 site · United StatesCompletes May 2028

Compare CT.gov Full analysis →

Recruiting

Sleep Healthy Using the Internet Mitigating Insomnia to Address Neurocognitive Difficulties (SHUTi MIND)

Phase 2InsomniaCognitive DysfunctionMild Cognitive Impairment

SHUTi OASISPatient Education

University of Virginia144 participants1 site · United StatesCompletes Jan 2028

Compare CT.gov Full analysis →

Completed

Results posted

The Efficient Brain Study

Phase 2Metabolism - Cerebral Energy

Fermented Papaya PreparationGranulated Sugar

University of Florida30 participants1 site · United StatesCompletes Jul 2018

Compare CT.gov Full analysis →

Completed

Results posted

Metformin in Amnestic Mild Cognitive Impairment

Phase 2Mild Cognitive Impairment

MetforminPlacebo

Columbia University80 participants1 site · United StatesCompletes Feb 2012

Compare CT.gov Full analysis →

Completed

Results posted

Valacyclovir for Mild Cognitive Impairment

Phase 2Mild Cognitive ImpairmentHerpes Simplex 1Herpes Simplex 2

Valacyclovir hydrochloride 500mg capletPlacebo sugar pill caplet

New York State Psychiatric Institute50 participants1 site · United StatesCompletes Oct 2024

Compare CT.gov Full analysis →

1–15 of 27